Emilie Solymoss
RESEARCH PROJECT
Defining How Cancer Derived Extracellular Vesicles Educate Neutrophils in Breast Cancer Metastasis
Breast cancer is the cancer with the highest incidence in women, and the emergence of metastatic disease signifies poor prognosis for these patients. Metastatic progression can be enhanced through the action of innate immune cells, with a prominent pro-metastatic role ascribed to neutrophils and the release of neutrophil extracellular traps (NETs), called NETosis. Emerging data shows that neutrophils readily uptake circulating cancer-derived extracellular vesicles (EVs). Cancer-derived EVs regulate critical steps of the metastatic cascade and modulate pro-tumor phenotypes in recipient cells.
My research project focuses on characterizing cancer-derived EVs and identifying cancer-EV-specific cargo that promotes pro-tumor functions in recipient neutrophils.
BACKGROUND
I completed my bachelor's degree in Microbiology and Immunology at McGill University. In Fall 2020, I joined the Siegel Lab as a Master of Science student in Experimental Medicine and transferred to the Ph.D. program in fall 2022.
CONTACT INFO
Rosalind and Morris Goodman Cancer Research Centre - McGill University
1160 Pine Ave. West (Room 508)
Montreal, Quebec (Canada)
H3A 1A3
T. 514.398.8889
F. 514.398.6769